Apexbio Technology LLC TAK-632 1228591-30-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A82265.1

TAK-632 (CAS 1228591-30-7) is a selective inhibitor of RAF kinase isoforms including BRAF CRAF and the mutant BRAF-V600E exhibiting IC50 values of 8 3 nM 1 4 nM and 2 4 nM respectively By targeting the RAF family of serine/threonine kinases TAK-632 disrupts the RAS-RAF-MEK-ERK signaling pathway implicated in MAPK cascade regulation In cellular assays TAK-632 promotes BRAF-CRAF dimerization and demonstrates potent antiproliferative effects in A375 and SK-MEL-2 melanoma cell lines with GI50 values of 6 nM and 11 nM respectively In vivo oral administration in SK-MEL-2 xenograft models inhibits ERK phosphorylation and tumor growth without notable toxicity TAK-632 is suitable for investigating RAF-driven signaling and drug resistance in oncogenic pathway studies

Catalog No. 50-000-90166