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Medchemexpress LLC Tak-960 dihydrochloride | 2320307-83-1 | C27H36Cl2F3N7O3 | 10 MM 1 ML
Supplier: Medchemexpress LLC HY15160B10MM/1ML
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 nM and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and demonstrates significant efficacy against various tumor xenografts.
- Acts as a selective inhibitor of polo-like kinase 1 (PLK1)
- Shows inhibitory activities against PLK2 and PLK3
- Causes accumulation of G2-M cells
- Leads to aberrant polo mitosis morphology
- Increases phosphorylation of histone H3 (pHH3)
- Induces G2/M cell cycle arrest in HeLa cells without significant cytotoxicity
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against multiple tumor xenografts
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