Medchemexpress LLC TAK-960 dihydrochloride | C27H36Cl2F3N7O3 | 100 MG

Supplier:  Medchemexpress LLC HY15160B100MG

TAK-960 dihydrochloride is a potent, orally available, and selective inhibitor of polo-like kinase 1 (PLK1), demonstrating an IC50 of 0.8 nM. It also displays inhibitory effects on PLK2 and PLK3 with IC50 values of 16.9 nM and 50.2 nM, respectively. This compound has been shown to effectively inhibit the proliferation of various cancer cell lines and exhibits significant efficacy against multiple tumor xenografts in preclinical studies.

• Potent and selective PLK1 inhibitor (IC50 = 0.8 nM)
• Inhibits PLK2 and PLK3
• Induces G2/M cell cycle arrest in HeLa cells
• Inhibits proliferation across multiple cancer cell lines
• Exhibits significant efficacy against tumor xenografts
• Demonstrates substantial antitumor activity and good tolerability in animal models

Catalog No. 50-003-73935