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Cayman Chemical Talabostatmesylate 10mg
Supplier: Cayman Chemical 2900710 MG
A non-selective inhibitor of DPPs (IC50s = >4, 310, 4, 11, 560, and 390 nM for DPP-4, DPP-7, DPP-8, DPP-9, FAP, and PREP, respectively); inhibits proliferation of superantigen-stimulated human PBMCs (IC50 = ~10 nM); increases expression of a variety of cytokines and chemokines in tumors and tumor-draining lymph nodes in a WEHI-164 fibrosarcoma mouse model at 5 μg twice per day; reduces tumor growth in a variety of syngeneic mouse models; increases the efficacy of the antitumor antibodies rituximab and trastuzumab in Namalwa B cell lymphoma and LS180 colon carcinoma mouse xenograft models, respectively
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