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Apexbio Technology LLC TAME 901-47-3 200mg
Supplier: Apexbio Technology LLC B1379200
TAME (CAS 901-47-3) or Tosyl-L-arginine methyl ester is a small molecule inhibitor of the anaphase promoting complex/cyclosome (APC/C) a multisubunit ubiquitin ligase essential for mitotic progression TAME binds competitively to the APC/C interfering with the association of its coactivator Cdc20 and thereby suppressing APC/C-dependent ubiquitination and subsequent proteasomal degradation of key substrates such as cyclin B1 In Xenopus egg extracts TAME exhibits an IC50 of 12 M for APC/C inhibition This compound is widely employed in cell cycle research to investigate mitotic regulation APC/C function and ubiquitin-mediated proteolysis
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