Tamibarotene

Description

A retinoic acid receptor → (RAR→) agonist | CAS: 94497-51-5 | C22H25NO3 | 351.45 g/mol

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).

Solubility
Soluble to 50 mM in DMSO

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 94497-51-5
• Molecular Formula: C22H25NO3
• Molecular Weight (g/mol): 351.45
• MDL Number: MFCD00866188
• InChI Key: MUTNCGKQJGXKEM-UHFFFAOYSA-N
• Synonym: tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
• PubChem CID: 108143
• ChEBI: CHEBI:32181
• IUPAC Name: 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
• SMILES: CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12

• Color: White
• Quantity: 10 mg
• Merck Index: 14,9047
• Solubility Information: Soluble to 50 mM in DMSO
• Formula Weight: 351.44
• Physical Form: Solid
• Chemical Name or Material: Tamibarotene

Safety and Handling

RTECSNumber	DH6940000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only