Cayman Chemical TamInadent 50mg

Supplier:  Cayman Chemical 3279950 MG

An adenosine A2A receptor antagonist (Ki = 12 nM); selective for adenosine A2A receptors over adenosine A1-, A2B-, and A3 receptors (Kis = 2,500, 1,000, and 5,000 nM, respectively); increases the levels of IFN-γ secreted by tumor-associated T cells isolated from patient-derived lung tumors at 1 µM when used in combination with an antibody targeting PD-1 or PD-L1; reduces the number of lung nodules in an MCA-205 murine fibrosarcoma model of lung metastasis at 15 mg/kg per day; inhibits haloperidol-induced catalepsy in a rat model of Parkinson's disease motor symptoms at 3, 10, or 30 mg/kg

Catalog No. 50-294-7356