Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Tandutinib (MLN518) 387867-13-2 200mg
Supplier: Apexbio Technology LLC B1526200
Tandutinib (MLN518 CAS 387867-13-2) is a selective small molecule inhibitor primarily targeting FLT3 with additional activity against PDGFR and c-Kit In biochemical kinase assays Tandutinib exhibits IC50 values of 0 22 M for FLT3 0 20 M for PDGFR and 0 17 M for c-Kit It effectively inhibits tyrosine phosphorylation of both wild-type FLT3 and FLT3 mutants with IC50 values in the 30 100 nM range In cellular models Tandutinib demonstrates anti-proliferative effects in FLT3-ITD-positive cell lines (Molm-13 Molm-14) at low nanomolar concentrations whereas FLT3-ITD-negative cells are substantially less sensitive This compound is utilized in research investigating FLT3-mediated signaling and acute myelogenous leukemia (AML) pathogenesis
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?