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Medchemexpress LLC Tarafenacin (D-tartrate) | 1159101-48-0 | 99.9% | 558.48 | 10 MM 1 ML
Supplier: Medchemexpress LLC HY14825A10MM/1ML
Tarafenacin (D-tartrate) is a highly selective M3 muscarinic receptor antagonist with a Ki of 0.19 nM. It demonstrates significant potency in inhibiting carbachol-induced bladder contractions without affecting atrial contractions, showing approximately 200-fold selectivity over the M2 receptor and high urinary versus cardiac selectivity. It also exhibits a much higher binding affinity to M5 mAChR compared to solifenacin.
- Highly selective M3 muscarinic receptor antagonist
- Ki of 0.19 nM
- Approximately 200-fold selectivity over M2 receptor
- Potent in inhibiting carbachol-induced bladder contractions
- High urinary versus cardiac selectivity (199-fold)
- Higher binding affinity to M5 mAChR than solifenacin
- Appears as a white to off-white solid
- Soluble in DMSO at 100 mg/mL or greater
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