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Apexbio Technology LLC Tariquidar methanesulfonate, hydrate 625375-83-9 10mg
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Supplier:  Apexbio Technology LLC A385910

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Tariquidar methanesulfonate hydrate (CAS 625375-83-9) is a potent non-competitive inhibitor of P-glycoprotein (Pgp) a 170-kDa transmembrane efflux pump implicated in multidrug resistance By suppressing Pgp-associated basal ATPase activity tariquidar interferes with the cellular efflux of structurally diverse compounds In vitro assays demonstrate that its IC50 for Pgp inhibition ranges from 15 to 223 nM across different models Its activity is selective for Pgp with reduced efficacy in tumor cell lines exhibiting resistance mediated by other multidrug resistance proteins Tariquidar methanesulfonate is widely used in studies investigating drug transport blood-brain barrier permeability and mechanisms of chemoresistance

Catalog No. 50-000-93134


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