Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Tarloxotinib bromide | 1636180-98-7 | 98.75% | 681.77 | 1 ML
Supplier: Medchemexpress LLC HY1763210MM/1ML
Tarloxotinib bromide is an irreversible EGFR/HER2 inhibitor that is efficiently metabolized under hypoxia in human NSCLC cell lines. Cellular anti-proliferative and receptor phosphorylation assays show a 14-80 fold reduction of activity relative to TKI, demonstrating greater activity compared with erlotinib. In vivo studies show that treatment with clinically relevant doses leads to tumor regression and durable inhibition of WT EGFR tumor phosphorylation, and can regress WT EGFR NSCLC tumor models H125 and H1648.
- Irreversible EGFR/HER2 inhibitor
- Efficiently metabolized under hypoxia
- Greater activity compared with erlotinib
- Associated with tumor regression and durable inhibition of WT EGFR tumor phosphorylation
- Can regress WT EGFR NSCLC tumor models H125 and H1648
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?