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Medchemexpress LLC Tarloxotinib bromide | 1636180-98-7 | 98.8% | 681.77 | 10 MG
Supplier: Medchemexpress LLC 10MGHY17632
Tarloxotinib bromide is an irreversible EGFR/HER2 inhibitor intended for research use only. It is metabolized efficiently under hypoxia in human NSCLC cell lines, a process inhibited by oxygen. This product demonstrates greater activity compared with erlotinib.
- Irreversible EGFR/HER2 inhibitor.
- Hypoxia-activated.
- Effective in inhibiting WT EGFR in vivo.
- Shown to be metabolized efficiently under hypoxia.
- Overcomes erlotinib-resistance in preclinical NSCLC models.
- Associated with tumor regression and durable inhibition of WT EGFR tumor phosphorylation in xenograft models.
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