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Medchemexpress LLC TAS-103 dihydrochloride | 174634-09-4 | 98.5% | 406.31 | 50 MG
Supplier: Medchemexpress LLC HY13758A50MG
TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
- Dual inhibitor of DNA topoisomerase I/II.
- Active on CCRF-CEM cells with an IC50 value of 5 nM.
- Significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells.
- Highly cytotoxic to Lewis lung carcinoma (LLC) cells.
- Inhibits the viability of HeLa cells with an IC50 of 40 nM.
- Disrupts signal recognition particle (SRP) complex formation and induces destabilization of SRP14 and SRP19.
- Causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells without obvious body weight loss.
- Liposomal TAS-103 is more active than free TAS-103 in vivo.
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