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Medchemexpress LLC TAS-103 dihydrochloride | 174634-09-4 | MFCD00943251 | 98.5% | 406.31 | 100 MG
SDP

Catalog No. 5000350351
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TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II used for cancer research. It exhibits high cytotoxicity to Lewis lung carcinoma (LLC) cells with an IC50 value of 5 nM in CCRF-CEM cells. TAS-103 can also disrupt signal recognition particle (SRP) complex formation in HeLa cells, leading to destabilization and degradation of SRP14 and SRP19. In vivo, TAS-103 (30 mg/kg, i.v.) has been shown to significantly suppress tumor growth in mice bearing Lewis lung carcinoma (LLC) cells without obvious body weight loss.

  • Dual inhibitor of DNA topoisomerase I/II
  • Highly cytotoxic to Lewis lung carcinoma (LLC) cells (IC50 of 5 nM in CCRF-CEM cells)
  • Disrupts signal recognition particle (SRP) complex formation
  • Induces destabilization and degradation of SRP14 and SRP19
  • Suppresses tumor growth in mice with Lewis lung carcinoma
  • Liposomal form is more active

Catalog No. 50-003-50351 Supplier Medchemexpress LLC Supplier No. HY13758A100MG
May include imposed supplier surcharges.
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TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II used for cancer research. It exhibits high cytotoxicity to Lewis lung carcinoma (LLC) cells with an IC50 value of 5 nM in CCRF-CEM cells. TAS-103 can also disrupt signal recognition particle (SRP) complex formation in HeLa cells, leading to destabilization and degradation of SRP14 and SRP19. In vivo, TAS-103 (30 mg/kg, i.v.) has been shown to significantly suppress tumor growth in mice bearing Lewis lung carcinoma (LLC) cells without obvious body weight loss.

  • Dual inhibitor of DNA topoisomerase I/II
  • Highly cytotoxic to Lewis lung carcinoma (LLC) cells (IC50 of 5 nM in CCRF-CEM cells)
  • Disrupts signal recognition particle (SRP) complex formation
  • Induces destabilization and degradation of SRP14 and SRP19
  • Suppresses tumor growth in mice with Lewis lung carcinoma
  • Liposomal form is more active

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