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Medchemexpress LLC Tas-103 dihydrochloride (BMS-247615 dihydrochloride) | 174634-09-4 | 98.5% | 406.31 | 1 ML
Supplier: Medchemexpress LLC HY13758A10MM/1ML
Tas-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, utilized for cancer research. It demonstrates activity on CCRF-CEM cells with an IC50 value of 5 nM and is highly cytotoxic to Lewis lung carcinoma (LLC) cells. It also inhibits the viability of HeLa cells.
- Dual inhibitor of DNA topoisomerase I/II.
- Demonstrates activity on CCRF-CEM cells with an IC50 value of 5 nM.
- Elevates levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells.
- Highly cytotoxic to Lewis lung carcinoma (LLC) cells.
- Inhibits viability of HeLa cells, exhibiting an IC50 of 40 nM.
- Disrupts signal recognition particle (SRP) complex formation.
- Suppresses tumor growth in mice bearing Lewis lung carcinoma (LLC) cells in vivo.
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