Cayman Chemical TAS 115methnsulfonate 10mg

Supplier:  Cayman Chemical 3359310 MG

A multi-kinase inhibitor; an inhibitor of PDGFRα and PDGFRβ (IC50s = 0.81 and 7.06 nM, respectively), c-FMS (IC50 = 15 nM), VEGFR2 and VEGFR1 (IC50s = 30 and 140 nM, respectively), Met (IC50 = 32 nM), and FGFR2 (IC50 = 340 nM); inhibits Axl, c-Kit, Src, and FLT1; inhibits VEGF-induced VEGFR2 phosphorylation in HUVECs and Met phosphorylation in Met-amplified MKN45 cells; inhibits VEGF-dependent growth of HUVECs (IC50 = 0.019 µM); inhibits growth of Met-amplified MKN45 cells (GI50 = 0.032 µM); reduces tumor growth in a MKN45 mouse xenograft model (ED50 = 8 mg/kg)

Catalog No. 50-294-6569