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Medchemexpress LLC TAS-119 | 1453099-83-6 | 98.0% | 506.36 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY13737710MM/1ML

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TAS-119 is a potent, selective, and orally active Aurora A inhibitor. It demonstrates high selectivity for Aurora A over other protein kinases and exhibits potent antitumor activities.

  • Potent and selective Aurora A inhibitor with an IC50 of 1.0 nM.
  • Shows high selectivity for Aurora A over Aurora B (IC50 of 95 nM).
  • Enhances the antiproliferative effect of paclitaxel in various human cancer cell lines, including paclitaxel-resistant cells.
  • Dose-dependently enhances cell growth inhibition by taxanes.
  • Induces mitotic accumulation predominantly in tumor cells.

Catalog No. 50-003-50399


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