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Medchemexpress LLC Tas-119 | 1453099-83-6 | 98.0% | 506.36 | 50 MG
SDP

Catalog No. 5000349221
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TAS-119 is a potent, selective, and orally active Aurora A inhibitor with an IC50 of 1.0 nM. It demonstrates high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). This compound exhibits potent antitumor activities.

  • Enhances the antiproliferative effect of Paclitaxel in various human cancer cell lines, including Paclitaxel-resistant cells.
  • Increases cell growth inhibition by taxanes (Paclitaxel, Docetaxel, and Cabazitaxel) in HeLa cells.
  • Induces mitotic accumulation predominantly in tumor cells compared to normal diploid fibroblasts.
  • Induces phosphorylated histone H3 (pHH3) in nude rats with HeLa-luc xenografts.

Catalog No. 50-003-49221 Supplier Medchemexpress LLC Supplier No. HY13737750MG
May include imposed supplier surcharges.
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TAS-119 is a potent, selective, and orally active Aurora A inhibitor with an IC50 of 1.0 nM. It demonstrates high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). This compound exhibits potent antitumor activities.

  • Enhances the antiproliferative effect of Paclitaxel in various human cancer cell lines, including Paclitaxel-resistant cells.
  • Increases cell growth inhibition by taxanes (Paclitaxel, Docetaxel, and Cabazitaxel) in HeLa cells.
  • Induces mitotic accumulation predominantly in tumor cells compared to normal diploid fibroblasts.
  • Induces phosphorylated histone H3 (pHH3) in nude rats with HeLa-luc xenografts.

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