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Medchemexpress LLC Tas4464 | 1848959-10-3 | 99.2% | 10 MG
Supplier: Medchemexpress LLC HY12858610MG
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) with an IC50 of 0.955 nM. This compound inhibits cullin neddylation, leading to the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in various human cancer cell lines.
- Highly potent and selective inhibitor of NEDD8 activating enzyme (NAE)
- Inhibits cullin neddylation
- Induces accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines
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