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Medchemexpress LLC Tas4464 | 1848959-10-3 | 99.2% | 10 MG
SDP

Catalog No. 5000338866
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TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) with an IC50 of 0.955 nM. This compound inhibits cullin neddylation, leading to the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in various human cancer cell lines.

  • Highly potent and selective inhibitor of NEDD8 activating enzyme (NAE)
  • Inhibits cullin neddylation
  • Induces accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines

Catalog No. 50-003-38866 Supplier Medchemexpress LLC Supplier No. HY12858610MG
May include imposed supplier surcharges.
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TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) with an IC50 of 0.955 nM. This compound inhibits cullin neddylation, leading to the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in various human cancer cell lines.

  • Highly potent and selective inhibitor of NEDD8 activating enzyme (NAE)
  • Inhibits cullin neddylation
  • Induces accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines

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