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Medchemexpress LLC Tas4464 hydrochloride | 1848959-11-4 | 98.9% | 1 ML
Supplier: Medchemexpress LLC HY128586A10MM/1ML
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor that targets the NEDD8-activating enzyme (NAE) with an IC50 of 0.955 nM. It blocks the neddylation pathway, leading to the accumulation of CRL ubiquitin ligase substrates and subsequent induction of tumor cell apoptosis. This compound exhibits broad-spectrum antiproliferative and cytotoxic antitumor activity against various hematologic and solid tumor cell lines, as well as patient-derived tumor cells, while possessing a wide therapeutic window without obvious toxicity.
- Highly selective covalent inhibitor of NEDD8-activating enzyme (NAE)
- Blocks the neddylation pathway
- Induces tumor cell apoptosis
- Exhibits broad-spectrum antitumor activity
- Possesses a wide therapeutic window
- Suitable for research in hematologic malignancies and solid tumors
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