Medchemexpress LLC Tas4464 (hydrochloride) | 1848959-11-4 | 98.9% | 25 MG

Supplier:  Medchemexpress LLC 25MGHY128586A

TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) with an IC50 of 0.955 nM. It exhibits antiproliferative and cytotoxic effects with broad-spectrum antitumor activity against various hematologic and solid tumor cell lines and patient-derived tumor cells. This compound has a wide therapeutic window without obvious toxicity and is suitable for research in hematologic malignancies and solid tumors.

• Highly potent and selective NAE inhibitor
• Demonstrates broad-spectrum antitumor activity against various cancer models
• Induces tumor cell apoptosis
• Increases protein expression levels of CRL ubiquitin ligase substrates
• Inhibits migratory capacity of solid tumor cell lines
• Achieves complete tumor regression in various animal models
• Prolongs survival and reduces tumor burden in lymphoma models
• Possesses a wide therapeutic window without obvious toxicity

Catalog No. 50-003-41631