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AdipoGen Taspine
Supplier: AdipoGen AGCN20544M005
Chemical. CAS 602-07-3. Formula C20H19NO6. MW 369.4. Taspine is an alkaloid with multifunctional pharmacological properties, including apoptosis-inducing, anti-angiogenic, anticancer, cytotoxic, anti-inflammatory and wound-healing activities, thereby modulating multiple targets. Taspine is a potent acetylcholinesterase AChE inhibitor and wound healing promoter cicatrizant, by regulating the expression of keratinocyte growth factor KGF FGF-7 in early phases. Taspine has anticancer properties targeting DNA topoisomerase IB and was shown to be a dual topoisomerase inhibitor. Taspine is an apoptosis-inducing compound. It induces conformational activation of the pro-apoptotic proteins Bak and Bax, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. It induced tumor apoptosis in vitro and in vivo. Taspine can inhibit tumor angiogenesis acting as a multi-target VEGFR-2 inhibitor.
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