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Cayman Chemical TatsyndegrontrIfluoroace 10mg
Supplier: Cayman Chemical 3744210 MG
An α-synuclein knockdown peptide; binds to recombinant α-synuclein in a peptide-protein binding assay and reduces α-synuclein levels in primary rat cortical neuron cultures; reduces brain α-synuclein levels in M38 transgenic mice that overexpress human A53T mutant α-synuclein at 40 mg/kg; reduces phosphorylated α-synuclein levels in the substantia nigra and the pons, as well as neuroinflammation in a mouse model of spreading synucleinopathy; protects against dopaminergic neuron loss and rescues motor deficits in a mouse model of MPTP-induced Parkinson’s disease at 6 µmol/kg, i.p.
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