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Medchemexpress LLC Tauro-β-muricholic acid | 25696-60-0 | 99.91% | 515.70 | 1 MG
SDP

Catalog No. 5000426367
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Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). It inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential and simultaneously inhibits intestinal FXR signaling, which affects bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity.

  • Inhibits bile acid-induced hepatocyte apoptosis
  • Maintains mitochondrial membrane potential
  • Inhibits intestinal FXR signaling
  • Regulates bile acid metabolism
  • Reduces serum ceramide production
  • Downregulates the hepatic SREBP1C/CIDEA pathway
  • Useful in studying bile acid metabolism disorders
  • Useful in studying non-alcoholic fatty liver disease
  • Useful in studying colorectal cancer
  • Useful in studying liver fibrosis
  • Functions as a biomarker

Catalog No. 50-004-26367 Supplier Medchemexpress LLC Supplier No. HYN99331MG
May include imposed supplier surcharges.
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Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). It inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential and simultaneously inhibits intestinal FXR signaling, which affects bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity.

  • Inhibits bile acid-induced hepatocyte apoptosis
  • Maintains mitochondrial membrane potential
  • Inhibits intestinal FXR signaling
  • Regulates bile acid metabolism
  • Reduces serum ceramide production
  • Downregulates the hepatic SREBP1C/CIDEA pathway
  • Useful in studying bile acid metabolism disorders
  • Useful in studying non-alcoholic fatty liver disease
  • Useful in studying colorectal cancer
  • Useful in studying liver fibrosis
  • Functions as a biomarker

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