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Medchemexpress LLC Taurochenodeoxycholic acid | 516-35-8 | 499.70 | 250 MG
Supplier: Medchemexpress LLC 250MGHYN1429
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is a primary bioactive substance found in animal bile acid. It is known to induce apoptosis and exhibits significant anti-inflammatory and immune regulation properties.
- Induces apoptosis in NR8383 cells in a concentration-dependent manner.
- Augments PKC mRNA levels and activities.
- Increases JNK, caspase-3, and caspase-8 mRNA expression levels and activities.
- Decreases pulmonary coefficient and pathological damage in the lungs of model mice.
- Reduces TNF-α and TIMP-2 expression in pulmonary tissues in pulmonary fibrosis mice.
- Normalizes clinical inflammatory parameters and attenuates intestinal inflammation.
- Suppresses paw swelling and polyarthritis index in AA rats.
- Amends radiologic changes in AA rats.
- Suppresses overproduction and mRNA expression of TNF-α, IL-1β, and IL-6 in serum and synovium tissue.
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