Medchemexpress LLC TBK1/IKKε-IN-5 | 1893397-65-3 | 100.0% | 50 MG

Supplier:  Medchemexpress LLC HY12867950MG

This product is an orally active dual inhibitor for two specific kinases, with very low nanomolar inhibitory concentrations. It is designed for use in cancer research, particularly in the field of tumor immunity.

• Potent dual inhibition against targeted kinases (IC50: 1 nM, 5.6 nM).
• Enhances immune response to anti-PD-L1 treatments, inducing immune memory in animal models.
• Demonstrates antitumor activity and prolongs survival in animal models with anti-PD-L1 combination.
• Induces immunologic memory in tumor cells when combined with anti-PD-L1.
• Promotes IL-2 and IFN-γ secretion in T cells and IL-2 in Jurkat cells.
• Blocks immunosuppressive cytokine production by spheroid cell lines without cytotoxicity.
• Orally active for convenient administration.

Catalog No. 50-003-39770