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AdipoGen TcdB mAb recVIF137-E7
SDP

Supplier:  AdipoGen AG27B6335C050

Encompass_Preferred

Recombinant Antibody. Recognizes TcdB from Clostridioides difficile. Applications ELISA, FUNC, WB. Clone VIF137-E7. Isotype Human IgG1. Formulation Liquid. In PBS. Clostridioides difficile is a spore-forming, anaerobic, and gram-positive bacterium, that opportunistically colonizes human colon and induces diseases such as diarrhea and pseudomembranous colitis. The symptoms of C. difficile infection CDI are mainly caused by two primary exotoxins, TcdA and TcdB, released from the bacterium. Both TcdA and TcdB belong to the family of large clostridial toxins LCTs, which contain an N-terminal glucosyltransferase domain that modifies small GTPase proteins, a cysteine protease domain CPD that autocatalytically cleave the holotoxin in the cytosol, a combined domain for both delivery and receptor binding, and a C-terminal region consisting of series of combined repetitive oligopeptides CROPs.

Catalog No. 50-256-3111


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