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Medchemexpress LLC TCO-PEG4-NHS ester | 1621096-79-4 | 99.2% | C24H38N2O10 | 25 MG
Supplier: Medchemexpress LLC 25MGHY141167A
TCO-PEG4-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring a TCO group that facilitates an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. PROTACs are composed of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- TCO group facilitates inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine groups
- Utilizes intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
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