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  6. Sigma Aldrich Tco Peg4 Succinimidyl Ester 

Sigma Aldrich Tco Peg4 Succinimidyl Ester

Catalog No. 7904355MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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79-043-55MG 5 mg
79-043-525MG 25 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Succinimidyl ester/NHS (amine reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted, copper-free, click chemistry cycloaddition reactions with 1, 2, 4, 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules, without the need for a catalyst, to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported, and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility, less aggregation, and an increased distance between the amine to be modified and the reactive alkene.

Specifications

Molecular Formula C24H38N2O10
Linear Formula C24H38N2O10
MDL Number MFCD28118912
Quantity 5 mg
Synonym trans-Cyclooctene-PEG4-NHS
Molecular Weight (g/mol) 514.57 g/mol
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