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Cayman Chemical TCS ERK 11e 10mg

Supplier: Cayman Chemical 1993210 MG

An ALK1 and ALK2 inhibitor (IC50s 1 8 and 1 1 nM respectively) that can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 100 nM) without affecting TGF-B signaling less selective for ALK3 4 5 and 6 subtypes and the type II BMP receptor ActRIIA (IC50s 34 4 302 321 6 4 and 220 nM respectively)
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