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Apexbio Technology LLC Tenofovir Disoproxil Fumarate 202138-50-9 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A17555.1

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Tenofovir disoproxil fumarate is an antiviral nucleotide analog functioning as a nucleoside reverse transcriptase inhibitor (NRTI) Upon cellular uptake it undergoes enzymatic hydrolysis to form the active metabolite tenofovir subsequently phosphorylated to the diphosphate derivative This phosphorylated metabolite competitively inhibits HIV-1 reverse transcriptase and induces DNA chain termination In vitro studies using MT-2 cells and peripheral blood mononuclear cells (PBMC) have demonstrated suppression of HIV replication with reported EC50 values approximately 0 007 mol/L and 0 005 mol/L respectively This compound is routinely utilized in research investigating HIV replication mechanisms antiretroviral therapies and drug resistance profiles

Catalog No. 50-000-63049


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