AdipoGen TDO Anopheles gambiaeHis

Supplier:  AdipoGen AG40T0101C050

Protein. Full-length TDO Anopheles gambiae is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 50mM sodium phosphate pH 8.0, containing 0.15M sodium chloride, 0.2M imidazole and 10% glycerol. Purity >98% SDS-PAGE. Tryptophan 2,3-dioxygenase TDO is a heme-containing dioxygenase catalyzing the addition of molecular oxygen across the 2,3-double bond of the indole ring of tryptophan to form N-formylkynurenine NFK. In Anopheles gambiae, TDO is the only enzyme able to catalyze the first and rate-limiting step in L-Trp catabolism through the kynurenine pathway. Tryptophan is an essential amino acid for protein synthesis and also the precursor for production of a number of neurotransmitters, such as serotonin and melatonin in mosquitoes, the kynurenine pathway is essential for eye pigmentation.

Catalog No. 50-256-2766