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Apexbio Technology LLC TDZD-8 327036-89-5 200mg
Supplier: Apexbio Technology LLC B1249200
TDZD-8 (CAS 327036-89-5) is a selective non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3 ) exhibiting an IC50 of 1 4 M In addition to GSK-3 TDZD-8 also inhibits protein kinase C isoforms PKC I and PKC with IC50 values of 1 4 M and 1 1 M respectively Cellular studies have demonstrated that TDZD-8 suppresses both GSK-3 and PKC activity leading to reduced photodynamic therapy-induced neuronal necrosis and glial cell apoptosis Furthermore TDZD-8 has been shown to exert anti-leukemic effects in primary human leukemia cell models possibly through dual inhibition of PKC and FLT3 highlighting its utility in studies related to neuroprotection and leukemia
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