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Apexbio Technology LLC Telaprevir (VX-950) 402957-28-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A40315.1
Telaprevir (VX-950) is an inhibitor that targets the hepatitis C virus (HCV) NS3-4A protease an essential enzyme for HCV replication Structurally derived from the viral NS5A/5B substrate Telaprevir binds to the NS3-4A protease in a covalent reversible manner through a slow-binding and dissociation mechanism thereby interrupting viral polyprotein processing Experimental studies have demonstrated that Telaprevir inhibits genotype 1 (H strain) NS3 protease with a reported inhibition constant (Ki) of approximately 7 nM In HCV replicon cell assays Telaprevir exhibits antiviral activity effectively suppresses viral replication and delays the development of viral resistance showing synergy when combined with interferon-alpha (IFN- ) Telaprevir serves as a research tool for studying antiviral mechanisms and therapeutic combinations in preclinical HCV models
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