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Cayman Chemical TelmIsartn-d3 1mg

Supplier: Cayman Chemical 225681 MG

An inhibitor of Atox1 and CCS binds to purified Atox1 and CCS (Kds 6 8 and 8 2 M respectively) inhibits the interaction between Atox1 and domain 4 of ATP7B in the presence of zinc in a FRET-based assay at 100 M increases copper and ROS levels and decreases COX activity and lipid biosynthesis in H1299 cells at 10 M inhibits the proliferation of H1299 K562 MDA-MB-231 and 212LN cancer cells but not PIG1 HDF HaCaT or MCF-10A cells in a concentration-dependent manner reduces tumor growth in an H1299 mouse xenograft model at 100 mg/kg per day
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