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Medchemexpress LLC Telotristat ethyl | 1033805-22-9 | 98.9% | 1 ML
Supplier: Medchemexpress LLC HY13055A10MM/1ML
Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
- Reduces serotonin content in the periphery
- Prevents increase in blood neutrophil counts
- Provides significant protection in a mouse model of inflammatory bowel disease
- Protects mouse IBD model confirmed by histopathology evaluation
- Does not deplete enteric neuronal serotonin (5-HT) or alter constitutive gastrointestinal motility in mice
- Alleviates severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis
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