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Cayman Chemical TemozolomIde 25mg
Supplier: Cayman Chemical 1416325 MG
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
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