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Medchemexpress LLC TEPP-46 (ML-265) | 1221186-53-3 | 99.9% | 372.46 | 250 MG
Supplier: Medchemexpress LLC 250MGHY18657
TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, demonstrating minimal to no effect on PKM1, PKL, and PKR. It is intended for research use only.
- Potent and selective pyruvate kinase M2 (PKM2) activator
- AC50 of 92 nM for PKM2
- Shows minimal effect on PKM1, PKL, and PKR
- Exhibits good oral bioavailability, low clearance, and long half-life
- Achieves maximal PKM2 activation in A549 xenograft tumors
- Decreases intracellular acetyl-coA, lactate, ribose phosphate, and serine
- Inhibits LPS-induced Hif-1α and IL-1β, downregulating M1 markers
- Significantly inhibits FSL-1 and CpG-induced Il1b mRNA expression
- Inhibits Mtb-induced Il1b mRNA and boosts Il10 mRNA levels
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