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AdipoGen TEPP46 ML-265
Supplier: AdipoGen AGCR13687M005
Chemical. CAS 1221186-53-3. Formula C17H16N4O2S2. MW 372.5. . Potent and selective cell-permeable pyruvate kinase M2 PKM2 activator with little or no activity versus PKM1, PKL and PKR. Useful agent for immunometabolism research. Anticancer reducing tumor sizes in mice and anti-inflammatory agent. Shown to bind the enzyme PKM2 to promote formation of stable, enzymatically-active tetramers, thereby promoting the last rate-limiting step of glycolysis, converting PEP to pyruvate. In addition, it prevents PKM2 translocation to the nucleus resulting in reduced glycolysis and HIF-1alpha activation, causing diminished Warburg effect and IL-1beta production.
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