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Medchemexpress LLC Terbinafine | 91161-71-6 | 99.96% | 291.43 | 200 MG
Supplier: Medchemexpress LLC HY17395A200MG
Terbinafine (TDT 067) is an orally active and potent antifungal agent. It acts as a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. It also demonstrates antibacterial activity against certain Gram-positive and Gram-negative bacteria. This product is a click chemistry reagent, containing an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, dimorphic fungi, and filamentous fungi.
- Specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation.
- Active following topical application and highly effective in experimental dermatophytoses when administered orally.
- In fungi-infected guinea-pigs, a significant decrease in skin temperature is observed after the fourth treatment.
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