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Cayman Chemical Terpen Screeng LIbrary 50uL
SDP

Supplier:  Cayman Chemical 900337050 UL

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An inhibitor of the menin-MLL1 fusion protein interaction (Ki 0.104 nM) selectively inhibits the growth of ten leukemia cell lines expressing MLL1 fusion proteins (IC50s 13-37 nM) over HL-60 K562 and Reh leukemia cells expressing wild-type MLL1 (IC50s >1000 nM) reduces MLL-AF9-induced increases in the expression of MLL fusion protein target genes in MOLM-13 leukemia cells dramatically increases the survival of mice in a PDX mouse model of B-ALL at 120 mg/kg twice per day

Catalog No. 50-289-6134


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