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Medchemexpress LLC Terrestrosin D | 179464-23-4 | 5 MG
Supplier: Medchemexpress LLC HYN50745MG
Terrestrosin D is an orally active apoptosis inducer that causes cell cycle arrest at G1 and S phases, decreases mitochondrial membrane potential, and inhibits the growth of cancer cells and endothelial cells. It is being studied for potential use in castration-resistant prostate cancer and pulmonary fibrosis.
- Induces cell cycle arrest at G1 and S phases.
- Reduces mitochondrial membrane potential.
- Inhibits the growth of cancer cells and endothelial cells.
- Exhibits cytotoxicity in human normal liver and embryonic kidney cells.
- Potently inhibits the growth of human prostate cancer cell lines.
- Induces caspase-independent apoptosis in prostate cancer and endothelial cells.
- Leads to mitochondrial membrane potential depolarization.
- Increases VEGF secretion.
- Suppresses xenograft tumor growth in mice.
- Attenuates bleomycin-induced pulmonary inflammation and fibrosis in mice.
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