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Sigma Aldrich Tert-Butyl 4-(3-(Hydroxymethyl)Phenyl)Piperidine-1-Carboxylate

Catalog No. 917400100MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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91-740-0100MG 50 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.Portal: Building PROTAC™ Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 72897-07-5
Molecular Formula C32H49N5O4S -+ xHCl
Linear Formula C32H49N5O4S -+ xHCl
Quantity 50 mg
Synonym (2S,4R)-1-((S)-2-(10-aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; Crosslinker-E3 Ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader; VH032 conjugate
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