tert-Butyl diethylphosphonoacetate, 95%

Description

CAS: 27784-76-5 | C10H21O5P | 252.247 g/mol

tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,β-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,ß-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

Solubility
Not miscible or difficult to mix in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 27784-76-5
• Molecular Formula: C10H21O5P
• Molecular Weight (g/mol): 252.247
• MDL Number: MFCD00075414
• InChI Key: NFEGNISFSSLEGU-UHFFFAOYSA-N
• Synonym: tert-butyl diethylphosphonoacetate, tert-butyl 2-diethoxyphosphoryl acetate, diethyl boc-methyl phosphonate, diethoxy-phosphoryl-acetic acid tert-butyl ester, t-butyl diethylphosphonoacetate, diethyl phosphonoacetic acid tert-butyl ester, t-butyl diethyl phosphonoacetate, diethylphosphonoacetic acid tert-butyl ester, diethyl 2-tert-butoxycarbonylmethyl phosphonate, acetic acid, diethoxyphosphinyl-, 1,1-dimethylethyl ester
• PubChem CID: 2773685
• IUPAC Name: tert-butyl 2-diethoxyphosphorylacetate
• SMILES: CCOP(=O)(CC(=O)OC(C)(C)C)OCC

• Density: 1.074
• Boiling Point: 100°C to 103°C (1.5 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.431
• Quantity: 25 g
• Beilstein: 2050126
• Solubility Information: Not miscible or difficult to mix in water.
• Formula Weight: 252.25
• Percent Purity: 95%
• Chemical Name or Material: tert-Butyl diethylphosphonoacetate

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319 Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	000-000-0
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only