tert-Butyldimethylchlorosilane, 97%

Description

CAS: 18162-48-6 | C6H15ClSi | 150.721 g/mol

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

Solubility
Soluble in chloroform and ethyl acetate. Insoluble in water.

Notes
Moisture sensitive. Store in cool place. Incompatible with bases, metals, oxidizing agents and alcohols.

Specifications

Chemical Identifiers

• CAS: 18162-48-6
• Molecular Formula: C6H15ClSi
• Molecular Weight (g/mol): 150.721
• MDL Number: MFCD00000501
• InChI Key: BCNZYOJHNLTNEZ-UHFFFAOYSA-N
• Synonym: tert-butyldimethylsilyl chloride, tert-butyldimethylchlorosilane, t-butyldimethylchlorosilane, tert-butylchlorodimethylsilane, tbdms chloride, tert-butyl chloro dimethylsilane, chloro-tert-butyldimethylsilane, silane, chloro 1,1-dimethylethyl dimethyl, tbscl, t-butyldimethylsilyl chloride
• PubChem CID: 28928
• ChEBI: CHEBI:85071
• IUPAC Name: tert-butyl-chloro-dimethylsilane
• SMILES: CC(C)(C)[Si](C)(C)Cl

• Boiling Point: 124°C to 126°C
• Melting Point: 86°C to 89°C
• Quantity: 5 g
• Linear Formula: (CH₃)₃CSi(CH₃)₂Cl
• UN Number: UN2925
• Beilstein: 505999
• Flash Point: 22°C (72°F)
• Solubility Information: Soluble in chloroform and ethyl acetate. Insoluble in water.
• Formula Weight: 150.73
• Percent Purity: 97%
• Odor: Pungent
• Sensitivity: Moisture sensitive
• Density: 0.81
• Chemical Name or Material: tert-Butyldimethylchlorosilane

Safety and Handling

Hazard Category	H228-H314-H335
Hazard Statement	GHS H Statement H228-H314-H318 Flammable solid. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P210-P240-P241-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c
DOTInformation	Hazard Class: 8; Packaging Group: I
EINECSNumber	242-042-4
RTECSNumber	VV2000000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only