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Medchemexpress LLC TES-991 | 1883602-20-7 | 99.3% | 393.45 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY112619100MG

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TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM.

  • Potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM (hACMSD).
  • Able to significantly increase intracellular NAD+ levels.
  • Shows low blood clearance, with low volumes of distribution and half-lives (t1/2) of about 4.0 and 5.0 h after intravenous administration of 0.5 mg/kg.
  • A moderate systemic exposure is observed for the 2H-tetrazole analogue, with good systemic exposure recorded for the free acid after oral administration at 5 mg/kg.

Catalog No. 50-004-36304


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