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Medchemexpress LLC TES-991 | 1883602-20-7 | 99.7% | 393.45 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112619
TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM.
- Potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor with an IC50 of 3 nM.
- Significantly increases intracellular NAD+ levels.
- Shows low blood clearance with low volumes of distribution and half-lives of approximately 4.0 and 5.0 hours after intravenous administration (0.5 mg/kg).
- Blood concentrations are quantifiable for up to 8 hours after oral administration (5 mg/kg).
- Exhibits moderate systemic exposure for the 2H-tetrazole analogue and good systemic exposure for the free acid.
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