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AdipoGen Tetra-O-methylscutellarein

Supplier: AdipoGen CDXM0514M001

Chemical. CAS 1168-42-9. Formula C19H18O6. MW 342.3. Tetra-O-methylscutellarein is a bioactive component of Siam weed extract. It exhibits anti-inflammatory activity through inhibition of the NF-kappaB pathway. It suppressed IkappaB kinase complex alpha/beta IKKalpha/beta and Inhibitory-kappa-B-alpha IkappaBalpha, inhibiting p65 translocation and thereby suppressing COX-2 and iNOS expression. This compound is modulating bacterial resistance to antimicrobial drugs most probably via efflux pump inhibition. It also showed anti-mutagenic activity.
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