Tetrahydro-4H-pyran-4-one, 98%

Description

CAS: 29943-42-8 | C5H8O2 | 100.117 g/mol

It is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. It is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. It is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. It is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. It is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3

Solubility
Very soluble in water.

Notes
Store away from strong bases and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 29943-42-8
• Molecular Formula: C5H8O2
• Molecular Weight (g/mol): 100.117
• MDL Number: MFCD00006581
• InChI Key: JMJRYTGVHCAYCT-UHFFFAOYSA-N
• Synonym: tetrahydro-4h-pyran-4-one, 4-oxotetrahydropyran, tetrahydropyran-4-one, dihydro-2h-pyran-4 3h-one, 4h-pyran-4-one, tetrahydro, 4-thp, tetrahydro-2h-pyran-4-one, tetrahydro-pyran-4-one, 4-oxotetrahydopyran, tetrahydro-.gamma.-pyrone
• PubChem CID: 121599
• IUPAC Name: oxan-4-one
• SMILES: C1COCCC1=O

• Density: 1.084
• Boiling Point: 165°C to 167°C
• Flash Point: 62°C (144°F)
• Refractive Index: 1.453
• Quantity: 1 g
• Beilstein: 106463
• Solubility Information: Very soluble in water.
• Formula Weight: 100.12
• Percent Purity: 98%
• Chemical Name or Material: Tetrahydro-4H-pyran-4-one

Safety and Handling

Hazard Category	H226
Hazard Statement	GHS H Statement H227 Combustible liquid.
Precautionary Statement	P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378q-P501c
DOTInformation	Hazard Class: 3; Packaging Group: III
EINECSNumber	249-967-2
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only