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Sigma Aldrich Tetrazine-Peg5-Nhs Ester

Catalog No. 90091350MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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90-091-350MG 1 g
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.Tetrazine-PEG5-NHS ester (Tz-PEG5-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.

Specifications

CAS 24367-66-6
Molecular Formula C33H51P
Linear Formula C33H51P
Quantity 1 g
Synonym Cyclopentylbis(3,5-di-tert-butylphenyl)phosphine; Phosphine ligand for nickel catalysis
Molecular Weight (g/mol) 478.73 g/mol
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